⁃ For Part A and Part C (Healthy Participants):

• Participant must be 18 to 55 years of age inclusive, at the time of signing the informed consent form.

• Participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and cardiac monitoring (vital signs and 12-lead ECG).

• Part C only: Be of Japanese (Cohort C1) or Chinese (Cohort C2) ancestry. i. Born in Japan (Cohort C1) or China mainland, Hong Kong or Taiwan (Cohort C2); and ii. Descendent of 2 ethnic Japanese (Cohort C1) or Chinese (Cohort C2) parents and 4 ethnic grandparents; and iii. Have lived outside Japan (Cohort C1) or China mainland, Hong Kong or Taiwan (Cohort C2) for less than 10 years at the time of screening.

• Body weight greater than or equals to (\>=) 45 kilograms (kg).

• Body mass index (BMI) within the range 18-32 kilograms per square meter (kg/m\^2) (inclusive).

• Male or female of non-childbearing potential

⁃ For Part B (SLE participants):

• 18 to 65 years of age inclusive, at the time of signing the informed consent form

• Documented clinical diagnosis of SLE according to the (European alliance of associations of rheumatology \[EULAR\]/ American College of Rheumatology \[ACR\] SLE classification criteria)

• Body weight \>= 45 kg.

• BMI within the range 18-32 kg/m\^2 (inclusive).

• Male or female